The article is devoted to researching the transformation of approaches to designing medical facilities for children. The work justifies the transition from traditional functional and hygienic models to a complex paradigm of «health architecture», where space becomes an active participant in the therapeutic process. Based on an analysis of the historical development of approaches to design up to modern concepts of biogenic design - the key principles of formation of an ozone-producing environment have been identified. Special attention is given to the scientific substantiation of therapeutic impact of architectural decisions, confirmed by research in the field of proof design. The result of the study is a set of principles for forming an architectural environment, aimed at creating conditions for physical and psycho-emotional recovery of children. 

Keywords: architecture, health architecture, children’s medical institution, sustainable architecture, biogenic design, therapeutic environment, ecological approach, space psychology, zoning, navigation